在美国大型医疗保健系统的职场遗传测试后,医疗保健利用率和行为变化
Elizabeth Charnysh1, Subhamoy Pal2, Jonathan M Reader2
1The Jackson Laboratory for Genomic Medicine, Farmington, CT.
概括
工作场所遗传检测 (wGT) 结果表明风险增加促使员工之间显著的健康行为变化和医疗保健利用. 有信息的药物遗传学结果也导致了药物调整,突出了wGT.
科学领域:
- 职业健康 职业健康 职业健康 职业健康
- 基因组医学是一种基因组医学.
- 健康行为研究研究健康行为研究
背景情况:
- 工作场所遗传检测 (wGT) 越来越多地用于健康计划,以改善员工健康.
- 对wGT结果的健康影响和员工反应在很大程度上是未知的.
- 了解这些影响对于评估wGT的伦理和社会维度至关重要.
研究的目的:
- 为了探索员工在工作场所遗传测试 (wGT) 后的健康行为变化.
- 为了调查wGT.之后医疗保健利用的变化.
- 评估不同类型的wGT结果 (癌症,心脏病,药物基因组学) 对员工健康决策的影响.
主要方法:
- 电子调查对提供WGT的美国医疗保健系统的员工进行了管理.
- 分析了收到 wGT 结果的员工的数据.
- 使用后勤回归来确定与员工对wGT结果的反应相关的因素.
主要成果:
- 超过一半的受访者获得了wGT结果,12%表示癌症风险增加,9.5%表示心脏病风险增加.
- 风险增加的结果与健康行为 (aOR: 3.23) 和医疗保健利用率 (aOR: 8.60) 的变化有显著联系.
- 药物遗传学结果在15.2%的受试者中提供了药物变化信息,而非信息结果的受试者则为4.8%.
结论:
- 工作场所遗传测试可以导致显著的健康行为变化和增加医疗保健利用率.
- 从wGT获得增加风险的结果似乎是积极主动健康管理的催化剂.
- 通过wGT进行的药基因组测试可以直接影响药物管理,强调其临床实用性.
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