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强迫症患者的处方模式:回顾性,单中心研究
Joshua Knebel1, M Lindsey Hedgepeth Kennedy2
1Department of Pharmacy Practice, University of the Incarnate Word, San Antonio, Texas, USA.
Human psychopharmacology
|May 11, 2024
概括
美国的强迫症 (OCD) 治疗方法显示出多种药物治疗方法. 选择性血清素再吸收抑制剂是最常见的,但二二类药物的使用量很高,表明复杂的处方模式.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
背景情况:
- 强迫症 (OCD) 经常表现出对治疗的抵抗力.
- 处方模式的异质性来自于患者试用多种药物类别,反应有限的患者.
研究的目的:
- 调查强迫症药物治疗的选择和剂量.
- 提供美国当前处方趋势的概述.
主要方法:
- 一个城市学术医疗中心的电子病历的回顾性审查.
- 包括295名成年患者,主要诊断为强迫症 (DSM-5标准).
主要成果:
- 在93%的患者中使用了心理药物疗法.
- 选择性血清素再吸收抑制剂 (SSRI) 是最常见的 (85%),其次是二类药物 (47%) 和第二代抗精神病药物 (37%).
- 三环抗抑郁药 (13%) 和第一代抗精神病药 (2%) 是最少使用的.
结论:
- 遵循基于证据的指南,但增强策略显示异质性.
- 高二二类药物的使用可能与诸如延迟第一线药物的治疗效果等因素有关.
- 需要进一步研究文化,药物经济和药物遗传学对处方变异和结果的影响.
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