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常见的母亲感染与分娩结果的关联:一项跨国队列研究
Jian-Rong He1,2, Gabriella Tikellis3, Ora Paltiel4
1Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. jianrong.he@bigcs.org.
在怀孕期间常见的孕妇感染,如阴道和尿路感染,增加了早产和低出生体重的风险. 怀孕期间发烧与怀孕年龄小 (SGA) 婴儿有关.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 流行病学 流行病学
背景情况:
- 怀孕期间的孕妇感染是对出生不良结果的潜在担忧.
- 常见的感染和风险之间的关联,如早产和妊娠年龄小 (SGA),需要进一步调查.
研究的目的:
- 评估怀孕期间母亲自我报告的感染和不良分娩结果之间的关系.
- 专门研究国际队列中早产和SGA的关联.
主要方法:
- 利用了来自六个国际分娩队伍的120507名孕妇的数据.
- 分析了自我报告的感染 (如呼吸道,阴道,尿道) 和症状 (发烧,腹).
- 使用波桑回归和随机效应元分析来确定风险比率 (RR) 和95%置信区间 (CI).
主要成果:
- 阴道感染 (RR 1.10) 和尿路感染 (RR 1.17) 与早产风险增加有关.
- 这些感染也显示出与低出生体重有类似的关联.
- 怀孕期间发烧与SGA风险更高有关 (RR 1.07).
结论:
- 怀孕期间的阴道和尿路感染与早产和低出生体重的轻微增加有关.
- 怀孕期间发烧与SGA的风险增加有关.
- 建议对实验室确认的诊断进行进一步的研究,以验证这些发现.
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