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循环瘤细胞:对于局部晚期鼻癌的一个有价值的指标

Ting Liu¹, Jing Liu², Guimei Wang¹

¹Department of Radiation Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

|May 11, 2024

概括

治疗前和治疗后的介质细胞循环瘤细胞 (CTC) 和CTC计数与鼻癌 (NPC) 患者的预后不佳有关. 这凸显了液体活检对个性化NPC管理的实用性.

科学领域:

在瘤学瘤学.
分子诊断学分子诊断
癌症生物标志物癌症生物标志物

背景情况:

针对鼻癌 (NPC) 的个性化治疗正在推进.
循环瘤细胞 (CTC) 对于液体活检和个性化医学至关重要,但未得到充分利用.
了解CTC在NPC管理中的作用至关重要.

研究的目的:

研究NPC中治疗前和治疗后的CTC计数,表皮-介质细胞转换 (EMT) 亚型,临床特征和患者预后之间的关系.
支持液体活检在NPC管理中的应用.

主要方法:

对141位局部晚期NPC患者进行了回顾性研究.
在治疗前和后检测CanPatrolTM CTC检测.
将CTC分类为上皮细胞,混合细胞和介质细胞亚型.
分析CTC编目和EMT亚型与临床特征和生存结果的关联.

主要成果:

治疗前的CTC检测与N阶段和TNM临床阶段正相关.
治疗后间酶体CTC检测与N阶段相关.
治疗前和后的CTC清单与预后有负相关性.
治疗前和治疗后的间酶体CTC与总生存率 (OS) 的下降显著相关.
T阶段,N阶段,TNM临床阶段,以及与OS相关的EBVDNA.

结论:

治疗前和治疗后的间酶体CTC和CTC计数是NPC中预后不良的指标.
这些发现支持液体活检用于个性化的NPC治疗策略.

关键词:

循环中的瘤细胞.皮质-介质细胞过渡.液体活检液体活检鼻癌是指鼻癌.预后预后预测预测

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