酶生物标记物的通过皮肤传感是通过化学反应的探针修饰的皮肤上微针贴片在人类皮肤组织中启用的
Nazanin Poursharifi1, Morteza Hassanpouramiri1,2, Alexander Zink1,2
1Department of Medicine, Solna, Division of Dermatology and Venereology, Karolinska Institutet, Stockholm, 171 77, Sweden.
Advanced materials (Deerfield Beach, Fla.)
|May 11, 2024
概括
一个新的可穿戴生物电子贴片使用微针来通过皮肤传感氨酶 (Tyr),一种黑色素瘤生物标志物. 这项创新使得皮肤癌的早期诊断和皮肤状况的监测能够不受干扰.
科学领域:
- 生物医学工程 生物医学工程
- 皮肤病学 皮肤病学
- 生物传感技术的技术
背景情况:
- 可穿戴生物电子产品在健康监测和诊断方面取得了进步.
- 目前用于皮肤癌检测的方法,特别是黑色素瘤,缺乏非破坏性和持续监测能力.
- 需要改进的诊断工具,以便早期检测和管理皮肤癌.
研究的目的:
- 开发一种可穿戴的生物电子贴片,用于通过皮肤传感铁酶 (Tyr),这是一种黑色素瘤的关键生物标志物.
- 为了从人类皮肤组织中直接,电化学检测Tyr.
- 建立一种非破坏性的方法,用于持续监测皮肤,及早诊断皮肤异常.
主要方法:
- 开发一种可穿戴的生物电子贴片,其中包含微针阵列.
- 集成一个表面化疗响应智能探针,用于针对特定目标的轮胎检测.
- 电化学检测Tyr直接从ex vivo人类皮肤模型.
主要成果:
- 通过皮肤微针传感器来定量酶生物标记物的可行性.
- 在一个ex vivo皮肤模型中成功地直接量化了铁酶 (Tyr).
- 最初的性能分析表明,有可能快速而可靠的黑色素瘤诊断和皮肤子评估.
结论:
- 开发的透皮微针传感器为黑色素瘤诊断提供了一种新的方法.
- 这项技术为持续的皮肤监测和及时干预提供了一种非破坏性的手段.
- 该平台可以扩展到对具有设备修改的补充生物标志物的查.
相关概念视频
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Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
03:31Labeling DNA Probes
DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
01:27Transducer Mechanism: Enzyme-Linked Receptors
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include: