在行为状态过渡过程中,送和消毒电路对皮质体静态内神经元的活性进行差异控制
Marcel de Brito Van Velze1, Dhanasak Dhanasobhon1, Marie Martinez1
1ICM, Paris Brain Institute, Hôpital de la Pitié-Salpêtrière, Sorbonne Université, INSERM, CNRS, 75013 Paris, France.
Cell reports
|May 11, 2024
概括
运动活动在体感皮质中招募体静止素 (SST) 内神经元,但不是视觉皮质. 这种招募依赖于体输入,而不是VIP内部神经元活动,表明依赖上下文的感官处理.
科学领域:
- 神经科学是一个神经科学.
- 感官处理 感官处理
- 细胞神经科学 细胞神经科学
背景情况:
- 内神经元 (INs),特别是表达体静止素 (SST) 和血管活性肠 (VIP) 的INs,由行为背景调节.
- 在活跃状态期间IN招募的机制及其在感官皮层中的一致性尚未完全理解.
研究的目的:
- 调查运动活动如何在不同的感官皮层中招募SST-IN.
- 在此招聘中确定VIP-IN和感官通路的角色.
主要方法:
- 在小鼠体内体内电生理学.
- 光遗传和化学遗传的操纵.
- 计算建模. 计算建模.
主要成果:
- 运动活动在主要体感 (S1) 皮层中强烈招募SST-IN,但在视觉 (V1) 皮层中没有.
- 这种招募取决于体感体的体输入,而不是通过VIP-INs进行调解.
- 视觉输入抑制了SST-INs通过运动的调制.
- 模型模拟表明,不同比例的VIP和丘脑驱动活动解释了差异性的SST-IN参与.
结论:
- SST-INs在感官皮层中表现出上下文依赖的招聘,受行为状态和感官输入的影响.
- 与神经调节相结合的前进乳头通路对于通过SST-INs来适应感官处理至关重要.
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