子宫内膜异位症,分期,不孕不育和辅助生殖技术:是时候重新思考了
Baris Ata1, Edgardo Somigliana2
1Department of Obstetrics and Gynecology, Koç University School of Medicine, Istanbul, Turkey.; ART Fertility Clinics, Dubai, United Arab Emirates..
Reproductive biomedicine online
|May 11, 2024
概括
除管管功能障碍外,与子宫内膜异位症相关的不孕症是可疑的. 卵细胞和胚胎质量似乎正常,这表明辅助生殖技术对子宫内膜异位症患者有效.
科学领域:
- 生殖医学 生殖医学
- 妇科 妇科 妇科 妇科
- 不孕症研究 不孕症研究
背景情况:
- 除了输卵管粘附外,子宫内膜异位症导致不孕症的机制仍然不清楚.
- 盆腔炎症因素和子宫内膜受体受损是假设的贡献者.
- 目前的分期系统无法准确预测子宫内膜异位症患者的生育能力.
研究的目的:
- 评估子宫内膜异位症对女性生育能力的影响,特别是关于卵细胞和子宫内膜功能.
- 评估辅助生殖技术 (ART) 在患有子宫内膜异位症的女性中的有效性.
- 质疑子宫内膜异位症和不孕不育之间的直接联系,不包括输卵管功能障碍.
主要方法:
- 对ART循环数据的分析,包括卵细胞发育率和euploid胚胎细胞发育率.
- 怀孕和活产率的比较在卵细胞/胚胎接受者和没有子宫内膜异位症.
- 对子宫内膜异位症的手术或医疗治疗后的体内观察和结果的审查.
主要成果:
- 来自子宫内膜异位症患者的卵细胞显示出正常的发育潜力,可以成为欧普洛伊德母细胞囊.
- 子宫内膜受体似乎受到最小的影响,子宫内膜异位症患者的怀孕率相似.
- 对子宫内膜异位症的手术或医疗治疗并不总是改善生育结果.
结论:
- 与子宫内膜异位症相关的不孕症是可疑的,可能仅限于由于粘附而导致输卵管功能障碍的病例.
- 卵细胞和子宫内膜功能在很大程度上不受子宫内膜异位症的影响.
- 对子宫内膜异位症患者来说,ART与其他不孕症指标一样有效.
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