相关实验视频

Updated: Jun 26, 2025

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
06:10

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

192

通过有效地产生大规模的TCR-T细胞来增强抗瘤反应,这些细胞针对多个癌症抗原中的单个表位向单个表位

Obed Boadi Amissah1, Rajesh Basnet1, Wenfang Chen1

  • 1CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Shijingshan District, Beijing 100049, China.

Cellular immunology
|May 11, 2024
PubMed
概括

这项研究开发了一种高效的方法,用于大规模的T细胞受体 (TCR) -T细胞扩张,使用Xeno/Sera-free介质. 针对CTAG1和CTAG2抗原的共同表位增强了抗癌活性,提高了采用细胞治疗的疗效.

关键词:
收养T细胞疗法采用T细胞疗法癌症丸抗原基因1 (CTAG1) 的基因.癌症丸抗原基因2 (CTAG2) 的基因.免疫治疗是一种免疫疗法.固体瘤是一种固体瘤.

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