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格拉姆阴性细菌病,危险因素和儿童的结局
Dilan Demir Gumus1, Osman Oguz Demir2, Kubra Aykac3
1Hacettepe University Faculty of Medicine, Department of Pediatrics, Ankara, Turkey.
Diagnostic microbiology and infectious disease
|May 11, 2024
概括
这项研究发现,多药耐药的グラム阴性细菌,特别是Klebsiella spp.,是儿童血液感染 (BSI) 的主要原因. 抗卡巴胺耐药性增加显著影响BSI结果和死亡率.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 儿童传染病 儿童传染病
背景情况:
- 血流感染 (BSI) 在儿科卫生保健机构中构成重大威胁.
- 阴性细菌是常见的病原体,抗菌素耐药性增加使治疗复杂化.
- 了解阻力模式和风险因素对于有效的BSI管理至关重要.
研究的目的:
- 调查导致住院儿童BSI的グラム阴性细菌的流行病学和抗菌素耐药性模式.
- 确定与BSI相关的风险因素,并评估感染的结果.
- 分析随着时间的推移对碳烯和素抗性的趋势.
主要方法:
- 对儿童412次细菌病发作的回顾性分析.
- 细菌分离物的鉴定和抗微生物敏感性测试.
- 对临床数据,风险因素和患者结果的评估.
主要成果:
- 克莱布西埃拉 spp. 的种类. (43.9%),大肠杆菌 (13.5%),和亚辛托巴克特种类. (10.6%) 是最常见的グラム阴性细菌.
- 41.2%的分离物是多药耐药的,具有显著的广泛和泛药耐药率.
- 在27.6%的隔离物中发现了碳烯胺耐药性,显示出与胆固醇素耐药性一起的日益增长的趋势.
- 中枢静脉导管的使用和儿科重症监护室的入院是关键的危险因素.
- 耐卡巴胺的格拉姆阴性 (CRGN) 感染与较差的临床反应和较高的死亡率有关.
结论:
- 对多种药物耐药的克莱布西埃拉菌种类. 它们在对抗医院感染方面构成了重大挑战.
- 越来越多的CRGN感染病例对BSI临床结果和儿童死亡率产生不利影响.
- 需要有效的策略来应对日益增长的抗菌素耐药性在儿科BSI.的威胁.
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