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在GDM和T2DM群体之间的多种金属和神经递质相关性尿液水平的比较研究

Jia Yu¹, Caimei Wang², Yun Liu³

¹Department of Toxicology, Guilin Medical University, Guilin 541004, China.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

|May 11, 2024

概括

像和这样的重金属与2型糖尿病 (T2DM) 和妊娠期糖尿病 (GDM) 有关. 暴露可能会导致DNA损伤和神经变化,影响神经递质,并为预防提供见解.

科学领域:

环境毒理学环境毒理学
代谢障碍代谢障碍代谢障碍
神经科学是一个神经科学.

背景情况:

孕期糖尿病 (GDM) 和2型糖尿病 (T2DM) 的发病包括金属暴露.
金属积累可以诱导反应性氧物种 (ROS),导致DNA损伤和神经病变.

研究的目的:

研究重金属暴露,DNA损伤,神经递质变化和GDM和T2DM中的代谢变化之间的关系.
在这些条件下识别神经系统并发症的潜在生物标志物.

主要方法:

使用ICP-MS.分析尿液中的重金属和微量元素.
通过HPLC测量神经递质代谢物的量化.
使用HPLC-MS测量8-基-2'-脱氧氨酸 (8-OH-dG).
通过UPLC-MS进行代谢分析.

主要成果:

(Cd) 和 (Hg) 被确定为T2DM的危险因素.
在GDM和T2DM群体中观察到8-OH-dG和神经递质代谢物之间的正相关性.
具体的代谢物变化包括GDM中铁素和碳代谢物的上调和T2DM的下调.

结论:

尿中的Cd和Hg水平与血糖升高和DNA损伤标志物8-OH-dG相关.
这些因素可能会通过神经递质变化引发神经系统的改变.
在GDM和T2DM中,氨酸和碳素代谢物等特征代谢物都发生了变化,这表明监测和预防神经损伤的潜力.

关键词:

造成的DNA损伤是DNA损伤.孕期糖尿病孕期糖尿病金属金属金属金属神经损伤是因为神经损伤.第二种类型的糖尿病.

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