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使用孔诱导的水力动力学空洞化,改进了可控制尺寸的奇托桑-基尼纳米颗粒的制造:过程优化和性能评估

Kunming Zhang¹, Jianbin Zheng², Yun Xu²

¹School of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou 545006, China; Guangxi Key Laboratory of Green Processing of Sugar Resources, Liuzhou 545006, China; Guangxi Liuzhou Luosifen Research Center of Engineering Technology, Liuzhou 545006, China; Province and Ministry Co-sponsored Collaborative Innovation Center of Sugarcane and Sugar Industry, Nanning 530004, China.

Ultrasonics sonochemistry

|May 11, 2024

概括

液动力学化 (HC) 有效地制造出可控制大小的奇多-基尼纳米颗粒用于药物输送. 与传统技术相比,这种方法提供了更高的能源效率和颗粒大小的减少.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
化学工程是化学工程的重要组成部分.

背景情况:

基托纳米颗粒 (NP) 对生物医学应用具有前景.
制造大小可控的基托-基尼NP是具有挑战性的.
乳液交叉连接 (ECLK) 是NP生产的常用方法.

研究的目的:

调查使用孔间诱导的水力动力空化 (HC) 来增强可控制尺寸的基因交联酸 (基因-基因) 的制造.
为了优化HC参数和NP生产的孔板几何.
评估HC制造的NP的能源效率和药物传递潜力.

主要方法:

利用孔间诱导的水力动力腔化 (HC) 进行基托-基尼NP的乳液交联 (ECLK).
多样化的孔板几何形状,奇托桑分子重量,进出口压力和交叉连接温度.
使用SEM分析了NP大小,多分散性指数,生产产量和形态学.
进行了体外药物释放研究.

主要成果:

优化的孔板几何 (单孔,直径3.0毫米) 和入口压力 (3.0 bar) 产生了312.6nm大小的NP,多分散度指数为0.359.
最大生产收益率达到84.82%.
与超声波喇或高剪切均化方法相比,HC显示出优异的颗粒大小减小和分布控制.
经过HC处理的ECLK显著更节能.

结论:

孔间诱导的水力动力空化是一种高效的方法,用于生产可控制尺寸的基托-基尼纳米颗粒.
优化的HC工艺为NP制造提供了更高的效率和粒子特性.
这些NP由于其特性和体外释放行为,显示出作为药物输送系统的巨大潜力.

关键词:

生物材料是一种生物材料.基托桑纳米颗粒基托桑纳米粒子杰尼平 (Genipin) 是一个天才.水力动态化 (Hydrodynamic cavitation) 是一种水力动态化.孔孔板是一个孔孔板.

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