相关实验视频

Updated: Jun 26, 2025

In Vivo Modeling of the Morbid Human Genome using Danio rerio

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

数据库构建和对鱼类营养代谢疾病中涉及的基因的比较基因组学分析

Yuru Zhang¹, Junmei Zhang¹, Haiying Fan¹

¹College of Fisheries, Henan Normal University, Xinxiang 453007, PR China; College of Fisheries, Engineering Technology Research Center of Henan Province for Aquatic Animal Cultivation, Henan Normal University, Xinxiang 453007, PR China.

Comparative biochemistry and physiology. Part D, Genomics & proteomics

|May 11, 2024

概括

为鱼类营养代谢疾病创建了一个新的基因数据库,揭示了跨物种的高基因保护. 该数据库有助于确定水产养殖业疾病预防和治疗的新目标.

科学领域:

水产养殖是水产养殖的一种方式.
鱼类遗传学鱼类遗传学
营养代谢性疾病营养代谢性疾病

背景情况:

营养代谢性疾病是密集水产养殖的一个重大挑战,由影响能量代谢的遗传和环境因素驱动.
了解这些疾病的遗传基础对于疾病管理和行业进步至关重要.
现有的鱼类营养代谢疾病基因数据库有限,需要进一步研究.

研究的目的:

为鱼类营养代谢疾病构建一个新的基因数据库.
分析基因保护,并在关键水产养殖物种中识别物种特异性基因.
为制定有针对性的疾病预防和治疗策略提供基础.

主要方法:

利用KEGG,OMIM和科学文献的数据来构建基因数据库.
专注于斑马鱼 (Danio rerio) 和五种经济重要鱼类:鱼 (Cyprinus carpio),鱼 (Takifugu rubripes),鱼 (Larimichthys crocea),鱼 (Oreochromis niloticus) 和鱼 (Oncorhynchus mykiss.) 这三种鱼类.
采用比较系统生物学方法来分析基因保存和识别独特的基因.

主要成果:

编制了一个全面的数据库,包含每个研究物种的基因计数.
在所有六种物种中发现了超过54.9%的营养代谢疾病的基因保存.
在大型黄鱼,鱼和彩虹鱼中确定了13种新型物种特异基因.

结论:

构建的基因数据库为鱼类营养代谢疾病提供了宝贵的见解.
高基因保存表明共享的潜在机制,而物种特异性基因呈现新的治疗点.
这项研究为推进水产养殖中的疾病管理提供了至关重要的资源.

关键词:

比较系统生物学比较系统生物学鱼类基因组数据库鱼类基因组数据库凯格 (KEGG) 是一个美国国家银行 (NCBI)营养代谢性疾病营养代谢性疾病 OMIMIMIM OMIMIM 在这个问题上.

更多相关视频

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

Published on: March 31, 2015

Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish

Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish

Published on: October 27, 2017

相关概念视频

Evolutionary Relationships through Genome Comparisons

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

Genetic Screens

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...