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病理性T3非小细胞肺癌与卫星结节:数量或大小,有什么关系?

Pietro Bertoglio¹, Filippo Tommaso Gallina², Vittorio Aprile³

¹Division of Thoracic Surgery, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

|May 11, 2024

概括

非小细胞肺癌 (NSCLC) 中卫星结节的总大小是整体存活率的独立预测指标. 两个以上的结节可能表明死亡和复发的风险更高.

科学领域:

在瘤学瘤学.
胸部外科手术胸部外科手术
癌症研究癌症研究

背景情况:

非小细胞肺癌 (NSCLC) 具有内卫星结节被归类为T3 (T3SN).
了解T3SN瘤的特征对于预测患者的结果至关重要.
这项研究研究了T3SN NSCLC的特征及其对整体生存期 (OS) 的影响.

研究的目的:

分析T3SN NSCLC的主要特征.
确定这些特征对整体存活率 (OS) 的影响.
为了确定T3SN NSCLC的预后因素.

主要方法:

对102名在2005年至2020年间接受手术的pT3SN NSCLC患者进行了回顾性多中心研究.
排除标准包括多焦点地面玻璃不透明度,诱导疗法,N3和第四阶段疾病.
测量包括最大结节直径 (LgN),最小结节直径 (SmN),总瘤直径 (TS) 和卫星结节数量 (SN).

主要成果:

瘤大小 (LgN,TS) 和卫星结节的数量 (SN) 与淋巴结转移和内脏膜侵袭相关.
五年后的正常运行率为65.1%.
多变量分析确定TS作为OS的独立预后因素 (HR 1.116,p=0.034). 在pN0患者中,LgN和非腺癌组织学是OS的显著预后因素.

结论:

瘤大小与T3SN NSCLC的局部侵入性有关.
总瘤大小 (TS) 是总生存率 (OS) 的独立预后因素.
患有两个以上卫星结节 (SN) 的患者可能面临死亡和复发的风险增加.

关键词:

非小细胞肺癌是非小细胞肺癌.预测预后预测预测卫星结节卫星结节阶段化系统分阶段化系统.外科手术手术手术

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