脊柱突出的神经元在面腹中髓中共同调节运动和交感声调
Zicong Zhang1, Junfeng Su1, Jing Tang1
1F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA; Department of Neurology and Ophthalmology, Harvard Medical School, Boston, MA, USA.
Cell
|May 11, 2024
概括
在面向腹中髓 (rVMM) 的下降脊柱突出神经元 (SPN) 协调肌肉和交感活动. 这些SPN控制着对行为至关重要的体力运动和自主功能.
科学领域:
- 神经科学
- 自主神经系统
- 发动机控制
背景情况:
- 协调的体和自主功能对于复杂的行为至关重要.
- 控制这些协调的神经回路仍然不完全理解.
研究的目的:
- 调查面腹中髓 (rVMM) 中下垂脊柱突出神经元 (SPN) 在调节体运动和交感活动中的作用.
- 阐明 rVMM SPN 控制协调电机和自主输出的机制.
主要方法:
- 在麻醉小鼠中对不同SPN群体进行光遗传刺激.
- 解剖学追踪以确定SPN内化目标.
- 纤维光度记录以将SPN活动与兴奋状态和生理音调相关联.
主要成果:
- 刺激刺激性rVMM SPNs增加了体运动和同情活动,同时抑制了基底音调和运动障碍.
- 对抑制性rVMMSPN的光刺激降低了这两种活动.
- 这些SPN激活了交感前神经元和脊柱运动区域.
- 在不同的兴奋状态下与肌肉和同情度相关联.
- 在REM睡眠期间抑制rVMMSPNs会破坏肌肉和同情性低活性.
结论:
- rVMM SPN 作为关键的下降通道,整合体运动和同情控制.
- 这些神经元在调节肌肉度,交感输出以及运动和快速睡眠等行为状态方面起着至关重要的作用.
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