通过饮食调节的人类微RNA:一个范围审查
Gwen M Chodur1, Francene M Steinberg1
1Department of Nutrition, University of California-Davis, Davis, CA, United States.
Advances in nutrition (Bethesda, Md.)
|May 11, 2024
概括
饮食影响微RNA (miRNA) 基因表达,特别是在健康个体中. 了解这些饮食miRNA反应对于分析饮食干预及其代谢影响至关重要.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 营养科学 营养科学
背景情况:
- 微RNAs (miRNAs) 在转录后调节基因表达.
- miRNAs可能会调解饮食和代谢调节之间的联系.
- 为了进行干预分析,需要对饮食调节的miRNAs进行全面的注册.
研究的目的:
- 进行对人类通过饮食检查miRNA调节的研究的范围文献综述.
- 为了识别影响miRNA配置文件的食物和饮食模式.
- 评估miRNAs在分析饮食干预措施中的实用性.
主要方法:
- 在PubMed,SCOPUS,EMBASE和Web of Science的范围文献搜索.
- 纳入标准:人体研究,饮食干预/饮食挑战,纵向miRNA分析.
- 选了6167项研究,包括25项满足标准 (7项饮食挑战,18项饮食干预).
主要成果:
- 饮食干预显著调节人类的miRNA配置文件.
- 代谢健康的个体对饮食变化表现出更强烈的miRNA反应.
- 在研究设计,种群和miRNA识别方法中存在显著的异质性.
结论:
- miRNAs对各种饮食干预有反应.
- 需要进一步的研究来了解miRNA对饮食摄入的反应.
- 为了在未来的研究中获得可比和可靠的结果,需要标准化的方法.
相关概念视频
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
01:30Regulation of Food Intake
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