支气管病变恶化与FEV1的纵向变化之间的关联来自美国支气管病和NTM研究注册表的患者
Timothy R Aksamit1, Nicole C Lapinel2, Radmila Choate3
1Mayo Clinic, Rochester, MN, USA.
Respiratory medicine
|May 11, 2024
概括
频繁的支气管切除症恶化预示着未来的恶化和较低的肺功能. 虽然肺功能下降可能不会因恶化的频率而有所不同,但患有更多基线恶化的患者随着时间推移预测的FEV1%较低.
科学领域:
- 肺部病理学 肺部病理学
- 呼吸系统医学 呼吸系统医学
- 临床流行病学临床流行病学
背景情况:
- 支气管切除症恶化是一个重要的临床问题.
- 了解恶化对疾病进展的长期影响至关重要.
研究的目的:
- 评估基线支气管切除症恶化和随后恶化的频率之间的关联.
- 为了识别与恶化频率相关的1秒内强迫呼气体积 (FEV1) 的纵向变化.
主要方法:
- 来自美国支气管炎和非结核性菌根研究登记处 (2008-2020) 的成年患者的回顾性队列研究.
- 目标1:在基线 (24个月) 和随访 (0-24个月和24-48个月) 期间评估恶化频率.
- 目标2:分析了24个月内预测的FEV1和FEV1%的变化,按基线恶化频率分层.
主要成果:
- 在0-24个月 (P=0.0085) 和24-48个月 (P<0.0001) 的随访期内,≥1个基线恶化病例的病史与≥1个恶化病例显著相关.
- 患有更多基线恶化患者在基线预测的FEV1%显著降低 (P<0.0001),12个月 (P=0.0002) 和24个月 (P<0.0001).
- 基线FEV1在恶化增加时较低,但FEV1下降在患有0,1或≥2次恶化的组之间没有显著差异.
结论:
- 频繁的支气管切除症恶化与未来恶化的可能性更高有关.
- 患有频繁恶化的患者表现出预测的较低基线FEV1 %,并且可能经历较差的长期肺功能.
- 虽然FEV1的下降可能不会因恶化的频率而有所不同,但频繁的恶化表明潜在的疾病进展.
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