用于局部控制出血的物理交叉连接的三聚酸装载的胺酸:使用两种不同的动物模型进行准备,表征和体内评估
Mai El Halawany1, Mohamed Khashaba2, Mohamed H H AbouGhaly3
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Ainy Street, Cairo 11562, Egypt.
International journal of pharmaceutics
|May 11, 2024
概括
这种新型的三胺敷料有效地通过使用特兰克萨姆酸阻止出血. 它在体外和体外模型中都显示出显著的静血改善,为伤口管理提供了有前途的解决方案.
科学领域:
- 生物材料科学 生物材料科学
- 血液静止研究 血液静止研究
- 药物输送系统 药物输送系统
背景情况:
- 有效的血液静止对于治疗外科手术出血和创伤伤害至关重要.
- 传统的静血剂通常在有效性和应用方面存在局限性.
- 开发具有可控制药物释放的先进伤口包裹是积极研究的领域.
研究的目的:
- 为了制定和表征一种新型的三聚胺连接剂,其中包含用于增强血液静止的松酸.
- 评估药物释放动力学和开发的敷料的胀特性.
- 为了评估在体外和体内血静效果的tranexamic酸加载的包装.
主要方法:
- 用氨酸,聚乙烯醇/卡帕卡拉和乙烯基纤维素层制造三层化敷料.
- 物理化学表征包括福里埃变换红外光谱学用于交叉连接确认.
- 在实验室中,超过8小时的胀和松酸释放研究.
- 在体外血液凝固测试中使用人类血液.
- 在老鼠尾巴截肢和子骨缺陷模型中的体内血静评估.
主要成果:
- 通过红外光谱学证实,通过结合证实了三层酸盐结构.
- 增加的层数与减少的胀和持续8小时释放的三胺酸相关.
- 在体外研究表明,凝血时间减少了70.5%.
- 在体内研究显示出显著的血液静止改善:大鼠动脉的血流控制速度提高了59%,子骨缺陷的血液静止时间减少了80%.
结论:
- 研发的三胺敷料通过持续释放的三胺酸有效控制出血.
- 包裹表现出显著的体外和体内静血能力,表现优于对照.
- 这种含有松酸的包裹是一种有希望的先进材料,用于有效的伤口血液静止.
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