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Elizabeth Glanet Durom¹, V A Aneesha¹, Nerella Venkata Pavan Kumar¹

¹Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar-243122, UP, India.

Reproductive toxicology (Elmsford, N.Y.)

|May 11, 2024

概括

在老鼠怀孕期间暴露于埃塞翁农药造成了严重的孕产妇伤害,包括减轻体重增加和器官损伤. 它还导致严重的胎儿毒性,在后代中观察到发育异常和器官损伤.

科学领域:

毒理学毒理学毒理学
生殖毒理学生殖毒理学
环境健康环境健康

背景情况:

像ethion这样的有机酸农药对环境和公共健康构成风险.
了解ethion的特定毒理特征对于风险评估至关重要.

研究的目的:

在老鼠模型中研究埃西昂对母亲和胎儿的毒性.
评估在关键发育时期暴露于乙的剂量依赖性影响.

主要方法:

怀孕的老鼠从妊娠第6天到第19天服用了不同剂量的乙 (0.866.9毫克/公斤).
通过体重,器官功能测试,氧化应激标志物和组织病理学来评估母亲的毒性.
胎儿毒性通过身体状况,粗体检查,胎儿和胎盘的形学和病理学来评估.

主要成果:

埃塞翁的暴露导致了对母体体重增加的剂量依赖性减少和胎儿再吸收的增加.
在母体中观察到氧化应激 (MDA) 的 elevated标志物和改变的抗氧化剂水平 (GSH,SOD,catalase).
记录了严重的肝脏和脏毒性,子宫和胎盘损伤以及胎儿发育异常,包括骨发育不良.

结论:

产前埃塞翁暴露会引起显著的孕产妇毒性,影响体重,器官功能和生殖组织.
埃塞翁对胎儿发育构成相当大的风险,导致胎儿体重减少,器官损伤和骨形.
这些发现凸显了埃西昂的致病性和有毒性潜力,强调需要仔细监管和风险管理.

关键词:

达姆达姆达姆达姆是什么意思埃塞翁 (Ethion) 是一个古老的传说.胎儿的胎儿是一个胎儿.产前暴露在产前暴露.它们是老鼠,老鼠,老鼠.

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