相关实验视频

Updated: Jun 26, 2025

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

济金可以通过抑制NF-κB和MAPK信号通路来改善急性喉炎

Hong Huang¹, Dan Wu², Qing Li¹

¹State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300353, People's Republic of China; High-throughput Molecular Drug Screening Centre, Tianjin International Joint Academy of Biomedicine, Tianjin, 300070, People's Republic of China.

Journal of ethnopharmacology

|May 11, 2024

概括

济金 (JGD) 通过通过NF-κB和MAPK通路减少炎症,有效治疗急性喉炎 (AP). 这项研究证实了JGD对喉疾病的传统用途.

科学领域:

药理学药理学是指药理学的学科.
传统中国医药传统中国医药
炎症研究炎症研究

背景情况:

吉 (Jiegeng) (JGD) 是一种传统的中医药,在治疗喉和肺部疾病方面有着悠久的历史.
它在治疗急性喉炎 (AP) 中的特定药理作用和机制需要阐明.

研究的目的:

调查JGD对急性喉炎 (AP) 的药理学影响.
探索JGD在AP治疗中的作用的潜在机制.

主要方法:

使用UPLC-MS.使用JGD的化学分析.
在RAW 264.7细胞中对抗炎作用 (NO产生,细胞因子mRNA表达) 的体外评估.
在氨诱导的AP模型中对JGD的体内评估,包括组织病理学,血清细胞因子分析 (IL-6,MCP-1) 和亡基因表达 (caspase-8,caspase-3).
西方涂抹分析关键信号通路蛋白质 (NF-κB,MAPK).

主要成果:

在JGD中发现了9种活性化合物.
在实验室中,JGD通过抑制氧化 (NO) 生产和调节细胞因子mRNA表达,显示出显著的抗炎作用.
在体内,JGD改善了喉组织病理学,降低了血清IL-6和MCP-1水平,并抑制了与亡相关的基因表达.
在AP模型中,JGD有效抑制了NF-κB和MAPK信号通路.

结论:

吉煮料通过施加抗炎作用来缓解急性喉炎.
JGD的治疗作用涉及NF-κB和MAPK信号通路的调制.
这些发现科学支持JGD用于治疗喉疾病的传统应用.

关键词:

急性喉炎是一种急性喉炎.这是一种抗炎症药物.吉的蒸煮液是什么意思通过NF-κB和MAPK通道.

更多相关视频

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

相关概念视频

Acute Pharyngitis

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:

Chronic Pharyngitis

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...

NF-κB-dependent Signaling Pathway

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...

Cells of the Innate Immune Response

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...

GPCRs Regulate Adenylyl Cylase Activity

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...