在接受辅助生殖技术的妇女中,暴露于酸盐和肝功能之间的关联
Yi Wang1, Li Yin1, Yao-Yao Du1
1Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
Environmental toxicology and pharmacology
|May 11, 2024
概括
暴露于甲酸盐可能会对接受辅助生殖技术 (ART) 的妇女的肝功能产生负面影响. 研究发现了甲酸代谢物和肝功能指标的改变之间的关联,表明潜在的肝毒性.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生殖医学 生殖医学
背景情况:
- 酸盐是常见的环境污染物,在动物模型中已知有肝毒性.
- 了解酸盐对人类肝功能的影响至关重要,特别是在像接受ART治疗这样的脆弱人群中.
研究的目的:
- 调查尿甲代谢物 (单个和混合物) 与血清肝功能指标之间的关联.
- 为了评估由于甲酸盐暴露而受到辅助生殖技术 (ART) 的妇女的潜在肝功能损害.
主要方法:
- 对764名接受ART治疗的女性进行横截面研究.
- 在尿样中的单个和混合甲酸代谢物的分析.
- 线性回归和贝叶斯核机器回归模型来评估与血清肝功能测试 (LFT) 的关联.
主要成果:
- 在单基甲酸盐和总蛋白/血球蛋白之间观察到逆相关性.
- 在单异布甲酸盐,单布甲酸盐 (MBP) 和AST/ALT比率之间发现了负相关性.
- MBP和全甲酸代谢物与 bilirubin 的积极关联;大多数代谢物与增加的玛-氨基转移酶 (GGT) 相关.
- 酸盐混合物与更高的 bilirubin 和 GGT 相关,以及较低的 AST/ALT 比率和总蛋白质.
结论:
- 在接受ART的妇女中,尿液中甲酸代谢物水平与肝功能指标的改变有关.
- 在这种人群中,暴露于甲酸盐可能会导致亚临床肝功能障碍.
- 需要进一步的研究来确认因果关系并探索临床影响.
相关概念视频
01:07Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
02:07Oogenesis
63.7K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.7K
01:22Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation
193
Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
Several distinctive characteristics distinguish glutathione conjugation from other phase II...
Several distinctive characteristics distinguish glutathione conjugation from other phase II...
193