目前对马类神经轴突变/马类退行性髓脑病变的最新见解
1Center for Equine Health, School of Veterinary Medicine, University of California, Davis, CA, USA.
Veterinary journal (London, England : 1997)
|May 11, 2024
概括
马类神经轴突变/马类退行性髓脑病变 (eNAD/EDM) 是一种与维生素E缺乏相关的马群常见的遗传性脊柱动力不良. 诊断需要尸检,但通过饮食和补充剂的预防是关键.
科学领域:
- 兽医神经学 兽医神经学
- 马类医学 马类医学
- 营养科学 营养科学
背景情况:
- 马类神经轴突变/马类退行性髓脑病变 (eNAD/EDM) 是马类的一种重大遗传性神经退行性疾病.
- 它是脊柱动力衰竭的第二大原因,由于神经疾病需要安乐死的马.
- 临床征兆包括对称的自感性动症和广泛的立场.
研究的目的:
- 审查目前对eNAD/EDM的理解.
- 突出诊断挑战和正在进行的死前检测研究.
- 概述当前的预防策略和管理建议.
主要方法:
- 关于马类神经轴突变/马类退行性髓脑病变的现有文献的综述.
- 对诊断标准和当前研究趋势的分析.
- 营养管理和补充方案的评估.
主要成果:
- 目前,没有针对eNAD/EDM的死前诊断测试.
- 确切的诊断依赖于中枢神经系统的死后组织病理学.
- 对遗传测试和生物标志物的研究正在进行中.
结论:
- 预防是主要的策略,重点是孕妇母马和小马的足够的维生素E摄入量.
- 饮食管理,包括放牧场的准入和针对性补充RRR-α-托哥菲醇至关重要.
- 监测血清维生素E水平至关重要,以避免潜在的过量补充和相关风险,如凝血病.
更多相关视频
06:35In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
Published on: June 15, 2018
19.3K
08:07Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery
Published on: October 4, 2024
314
相关概念视频
Encephalitis l: Introduction
27
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
27
Encephalitis ll: Pathophysiology
30
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
30
Hepatic Encephalopathy
71
DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic...
71
