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乙型肝炎病毒感染与扩散性大B细胞淋巴瘤的关联

Guodong Yu¹, Jijing Han¹, Jianmei Xu¹

¹From the Department of Hepatobiliary Surgery (Yu), from the Department of Pediatrics (Han), and from the Department of Hematology (Xu), Affiliated Hospital of Hebei University, Baoding, China.

Saudi medical journal

|May 11, 2024

概括

乙型肝炎表面抗原阳性 (HBsAg[+]) 状态与扩散性大B细胞淋巴瘤 (DLBCL) 患者的生存率降低有关. 这一发现凸显了对HBsAg[+] DLBCL病例集中临床关注的必要性.

科学领域:

在瘤学瘤学.
肝病学肝病学是一种肝病学.
临床医学临床医学

背景情况:

扩散性大B细胞淋巴瘤 (DLBCL) 是一种常见的非霍奇金淋巴瘤.
乙型肝炎病毒 (HBV) 感染是一个全球性的健康问题.
乙型肝炎病毒感染对DLBCL预后的影响需要进一步调查.

研究的目的:

为了描述DLBCL患者.
为了确定乙型肝炎表面抗原阳性 (HBsAg[+]) 状态是否影响DLBCL患者的存活率.

主要方法:

从2011年1月至2021年12月,对602例DLBCL病例进行了回顾性分析.
包括一般临床数据和生存时间分析.
应用单变量和多变量考克斯回归分析.

主要成果:

HBsAg[+]患者 (25.6%) 呈现出更先进的疾病,更高的IPI得分,B症状,肝功能受损和更高的复发率.
在HBsAg[+]患者中,平均整体存活时间为16.5个月,而在HBsAg[-]患者中为35个月.
HBsAg[+]状态是DLBCL预后更差的一个独立预测因素 (HR=1.46,p=0.017).

结论:

乙型肝炎表面抗原阳性是DLBCL预后较差的一个独立风险因素.
临床监测和管理策略应考虑DLBCL患者的HBsAg状态.
需要进一步关注HBsAg[+] DLBCL患者的研究.

关键词:

扩散的大B细胞淋巴瘤乙型肝炎病毒的感染.总体存活率总体存活率预后预后预后

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