红细胞分布宽度与大动脉狭窄患者全因死亡率之间的关联:一项回顾性研究
Benhui Liang1, Yiyang Tang1, Shien Li1
1Department of Cardiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Heart & lung : the journal of critical care
|May 11, 2024
概括
红细胞分布宽度 (RDW) 是大动脉狭窄症 (AS) 患者死亡率的重要预测因素. 较高的RDW水平独立地与AS中较高的90天和1年全因死亡风险相关.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 医疗信息学 医疗信息学
背景情况:
- 准确的风险分层对于治疗大动脉狭窄症 (AS) 患者至关重要.
- 红细胞分布宽度 (RDW) 是一个易于获取的血液学参数.
研究的目的:
- 研究RDW在AS患者的大群中对所有原因死亡率的预测价值.
- 在AS中使用MIMIC-IV数据库评估RDW的预后能力.
主要方法:
- 来自MIMIC-IV数据库的1,148名AS患者的回顾性分析.
- 利用Kaplan-Meier,物流和Cox回归分析来评估RDW和死亡率的关联.
- 采用多变量调整,倾向得分匹配和子组分析来控制混因素.
- 使用接收器操作特征 (ROC) 和决策曲线分析 (DCA) 评估预测性能.
主要成果:
- 较高的RDW水平与死亡风险的逐渐增加有关.
- 在多变量调整后的90天和1年的全因死亡率在患有RDW≥14.7%的患者中显著更高.
- RDW表现出强大的预测性能,与已建立的危急疾病得分 (AUC为0.741和0.75) 相似或超过.
结论:
- 升高的RDW是AS患者90天和1年全因死亡率增加的独立预测因素.
- RDW具有显著的预测能力,可以预测AS的结果.
- RDW为AS管理中的风险分层提供了一个有价值的工具.
相关概念视频
Aortic Regurgitation I: Introduction
1.6K
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
1.6K
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
1.2K
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
1.2K
Aortic Regurgitation III: Medical Management
598
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
598
Coronary Artery Disease I: Introduction
1.8K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
764
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
764
Aneurysm II: Clinical Manifestations and Diagnostic Studies
589
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
589


