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开发一个脏微生理系统硬件平台,用于微重力研究.

Kendan A Jones-Isaac1, Kevin A Lidberg1,2, Catherine K Yeung3,4

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一个新的芯片输液平台 (KCPP) 能够研究微重力.

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科学领域:

  • 太空生物学空间生物学
  • 脏生理学 脏生理学
  • 生物医学工程 生物医学工程

背景情况:

  • 目前用于在微重力下评估功能的方法缺乏灵敏度.
  • 现有的"芯片器官"模型与太空飞行约束不相容.
  • 早期发现功能障碍对宇航员健康至关重要.

研究的目的:

  • 为脏微生理模型开发和验证一个与太空飞行兼容的硬件平台.
  • 为了能够在微重力条件下研究脏靠近管管的功能.
  • 为了促进在太空中早期检测功能障碍.

主要方法:

  • 芯片输液平台 (KCPP) 的工程与关键组件:脏微生理系统 (MPS),外,门块,介质/固定盒和精密注射器.
  • 在国际空间站国家实验室 (ISSNL) 的两个任务 (CRS-17和CRS-22) 中部署了KCPP.
  • 收集近接管微生理系统 (PT-MPS) 废水,用于生物标志物和转录组学分析.

主要成果:

  • 在微重力条件下,KCPP成功支持脏MPS实验.
  • 为生物标志物分析实现了废水回收.
  • 适合转录组学分析的RNA被成功恢复,证明了系统的功能.

结论:

  • 芯片输液平台 (KCPP) 是一种可行的,半自主硬件解决方案,用于微重力中脏研究.
  • 在太空中,KCPP可以对功能和功能障碍机制进行敏感评估.
  • 这项技术有助于在太空环境中研究脏生理和疾病.