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Updated: Jun 26, 2025

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一个定量系统药理模型的血kallikrein-kinin系统失调在遗传性血管

Dan Sexton1, Hoa Q Nguyen1, Salomé Juethner1

  • 1Takeda Development Center Americas, Inc., Lexington, MA, USA.

Journal of pharmacokinetics and pharmacodynamics
|May 11, 2024
PubMed
概括

一个新的定量系统药理模型准确地模拟了遗传性血管 (HAE) 发作. 该模型预测了药物有效性降低与不坚持,并分析了最优的剂量治疗,如lanadelumab.

关键词:
布拉迪基尼尼尼尼尼尼尼尼尼遗传性血管腺 遗传性血管腺 遗传性血管腺卡利克莱恩-基宁系统拉纳德鲁马巴巴是什么意思量化系统药理学 药理学

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