双胞胎怀孕中的疫苗接种:怀孕前和怀孕期间的免疫接种之间的比较
Ran Svirsky1,2,3, Moran Landau Rabbi4, Ramzia Abu Hamad5
1Department of Obstetrics and Gynecology, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel. rsvirs@gmail.com.
Scientific reports
|May 11, 2024
概括
在双胞胎怀孕中,在怀孕前接种疫苗会导致与怀孕期间接种疫苗相比,中和抗体水平更高. 这表明,怀孕前接种疫苗可以在怀孕期间更好地预防COVID-19.
科学领域:
- 免疫学 免疫学 免疫学
- 产科 产科 产科 产科 产科
- 传染性疾病 传染性疾病
背景情况:
- 评估COVID-19疫苗接种时间对母亲和胎儿健康的影响至关重要,特别是在双胞胎怀孕等高风险怀孕中.
- 了解中和抗蛋白IgG (Anti-S-IgG) 抗体的发展是评估怀孕期间疫苗有效性的关键.
- 之前的研究已经探索了单独怀孕中疫苗反应,但针对双胞胎怀孕的具体数据仍然有限.
研究的目的:
- 在双胞胎怀孕中,根据接种疫苗的时间:怀孕前与怀孕期间,比较中和抗尖端蛋白IgG (Anti-S-IgG) 水平的发展.
- 评估疫苗接种时间,COVID-19感染和双胞胎怀孕中的Anti-S-IgG水平之间的关联.
- 为双胞胎怀孕妇女提供基于证据的建议,以提供最佳的COVID-19疫苗接种策略.
主要方法:
- 一项前性研究,涉及83名双胞胎怀孕的妇女,按疫苗接种状态分类 (怀孕前,怀孕期间或未接种疫苗).
- 采集三个血液样本用于抗S-IgG免疫诊断.
- 对疫苗接种史,PCR测试结果和临床结果的电子医疗记录的审查;年龄相匹配的非孕妇作为对照.
主要成果:
- 在怀孕前接种疫苗的妇女在怀孕期间接种疫苗的妇女相比,在第三个三个月内呈现出明显更高的中和抗S-IgG水平,而不管COVID-19感染状况如何.
- 感染COVID-19的未接种疫苗的孕妇经历了严重的疾病,而接种疫苗的妇女 (怀孕前或怀孕期间) 只有轻微的症状.
- 怀孕前感染与怀孕期间较低的Anti-S-IgG水平有关,而怀孕期间感染导致高抗体水平,特别是在那些怀孕前接种疫苗的人群中.
结论:
- 对于双胞胎怀孕,建议在怀孕前进行完整的COVID-19疫苗接种,以确保强大且持续的抗体保护.
- 怀孕期间的疫苗接种导致中和抗体水平降低,并且与双胞胎怀孕的孕前疫苗接种相比,疫苗的下降速度更快.
- 在双胞胎怀孕中,怀孕前接种疫苗似乎可以提供对严重的COVID-19结果的优越保护.
关键词:
BNT162b2 瑞/生物科技疫苗接种在COV-2-Trimeric S-IgG-b1 -b1中,我们可以使用COV-2-Trimeric.中和抗体的抗体.这是一个PCRPCR.这就是SARS-CoV-2病毒.双胞胎怀孕是什么意思 双胞胎怀孕是什么意思更多相关视频
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