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在雄性小鼠中,腹腔垂体通过几个途径促进觉醒

Xue-Fen Zhang¹, Yi-Dan Li¹, Yue Li¹

¹Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, 430071, China.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

|May 11, 2024

概括

腹部的垂体 (Ventrial subiculum) 是一个垂体.

科学领域:

神经科学是一个神经科学.
行为神经科学行为神经科学

背景情况:

腹部垂体 (vSUB) 是海马形成的一个关键输出.
它在清醒和兴奋调节中的作用尚不清楚.

研究的目的:

为了研究腹部 subiculum glutamatergic 神经元在清醒控制中的作用.
为了识别通过vSUB影响兴奋的神经回路.

主要方法:

在小鼠体内纤维光度和多通道电生理学记录.
对vSUB神经元及其通路进行光遗传和化学遗传操纵.
多巴胺受体对抗剂微注射.

主要成果:

腹腔潜膜的谷氨基基神经元在清醒期间非常活跃.
这些神经元的激活增加了清醒,焦虑类行为,并促进睡眠到清醒的过渡.
腹部垂体管道通往侧向下丘脑,核突外和前额叶皮质的通道促进兴奋.
多巴胺受体阻塞抑制了vSUB激活的唤醒促进作用.
抑制vSUB质质神经元可以降低兴奋.

结论:

腹腔体内质神经元在促进和维持清醒方面发挥着重要作用.
这些神经元通过投射到与兴奋相关的大脑区域来发挥作用.
多巴氨基信号参与调解vSUB的唤醒促进作用.

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