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牛皮B2组织表达和相关基因多态性在牛皮和它们与NB-UVB和Acitretin治疗的关系
Eisa Mohamed Hegazy1, Moustafa A El Taieb2, Mohammed H Hassan3
1Dermatology, Venereology and Andrology Department, Qena Faculty of Medicine, South Valley University, Qena, Egypt. eisa_mohamed4152@med.svu.edu.eg.
牛皮患者的plexin-B2水平显著高于牛皮患者,与疾病严重程度相关. 治疗降低了这些水平,这表明Plexin-B2在牛皮的发病过程中发挥了作用.
科学领域:
- 免疫皮肤学 免疫皮肤学
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 牛皮是一种慢性,免疫媒介的皮肤疾病,其病因不明.
- 参与免疫细胞功能的plexin B2是牛皮发育的潜在因素.
研究的目的:
- 在牛皮患者中评估Plexin-B2及其相关基因多态性 (SIRPγ-rs71212732) 的组织水平.
- 为了将plexin-B2水平与疾病严重程度和治疗反应相关联.
- 为了评估NB-UVB和阿西特雷丁治疗后Plexin-B2水平的变化.
主要方法:
- 一个单盲随机对照试验,涉及50名牛皮患者和50名健康对照.
- 通过ELISA测量组织Plexin-B2水平.
- 使用实时PCR和TaqManTM试验评估SIRPγ-rs71212732基因多态性.
- 使用牛皮区域和严重性指数 (PASI) 评分评估疾病严重程度.
主要成果:
- 与对照组相比,牛皮患者的组织Plexin-B2水平显著更高 (25.8 pg/g vs 2.9 pg/g).
- 增加的plexin-B2水平与牛皮的严重程度正相关 (严重与中度:32.7 pg/ml与13.6 pg/ml).
- 突变的"C"等位基因和SIRPγ-rs71212732的TC/TT基因型在患者中明显更为普遍.
- 在用NB-UVB和/或阿西特雷丁治疗后,组织素-B2水平下降.
结论:
- 素-B2在牛皮中受到上调,其水平与疾病严重程度相关.
- 基因多态SIRPγ-rs71212732与牛皮有关.
- 普莱克辛-B2可能在牛皮病的发病过程中发挥重要作用.
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