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Updated: Jun 26, 2025

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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在子宫内膜腺癌前体病变的遗传和表观遗传变化

Osamu Gotoh1, Yuko Sugiyama1,2, Akiko Tonooka3

  • 1Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Koto-ku, Japan.

The Journal of pathology
|May 12, 2024
PubMed
概括

这项研究揭示了PTEN突变和DNA甲基化变化驱动子宫内膜激增的进展. 这些分子变化是理解子宫内膜癌发育和区分多度增生阶段的关键.

关键词:
基因组甲基组组的DNA.非典型的子宫内膜增生症.驱动基因 驱动基因 驱动基因这是子宫内膜癌的癌症.胚胎内膜细胞分化宫内膜内膜状腺癌 (Endometrial Endometrioid Carcinoma) 是一个内膜内膜状腺癌.突变是一种突变.瘤细胞的转化转化非典型的子宫内膜增生症.

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