在一个研究所内为血液病注射Evusheld®的综合程序
Osamu Imataki1, Shunsuke Yoshida2, Tomoya Ishida2
1Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-Town, Kita-County, Kagawa, 761-0793, Japan. imataki.osamu@kagawa-u.ac.jp.
Annals of hematology
|May 12, 2024
概括
提克萨吉维玛和西尔加维玛 (EVA) 在血液恶性瘤患者中有效预防了SARS-CoV-2感染. 这种全面的预防策略表明,突破性感染的显著减少,毒性最小.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 提克萨吉维玛和西尔加维玛 (EVA,Evusheld®) 正在中和针对SARS-CoV-2的单克隆抗体.
- EVA已经证明了对COVID-19的预防和治疗益处.
- 日本血液学会为特定的患者群体推EVA,但机构管理有所不同.
研究的目的:
- 开发和实施一种系统的程序,用于在患有血液性恶性瘤的患者中进行全面的预防性EVA注射.
- 确保适当的管理,没有过度或不足的指示.
主要方法:
- 开发了一种系统的EVA注射程序,并将其应用于2022年11月至2023年3月的血液恶性瘤患者.
- 收集了患者数据,包括EVA的潜在疾病和适应症.
- 分析了EVA拒绝,给药设置,时间,毒性和突破性感染等结果.
主要成果:
- 包括178名患有潜在的髓状或淋巴状瘤的患者.
- 关键的适应症包括密集的血液性恶性瘤治疗和rituximab使用.
- 超过95%的人在3个月内接受了EVA;12.4%的人拒绝了. 没有观察到严重的毒性.
- 突破性SARS-CoV-2感染发生在5.2%的EVA接受者中,明显低于非接受者 (18.2%).
结论:
- 在血液性恶性瘤患者中,全面的EVA注射管理是可行的和有效的.
- 这一策略导致了更安全地完成预防,具有更好的临床影响.
- 预防性EVA显著减少了这一脆弱人群中突破性的SARS-CoV-2感染.
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