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Updated: Jun 26, 2025

Induction and Assessment of Class Switch Recombination in Purified Murine B Cells
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USP7通过稳定RUNX3促进IgA类切换,以激活生殖系转录

Bo Zhao1, Zhigang Xia2, Beibei Yang3

  • 1Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; Department of Pediatrics, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong 518107, China; Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China.

Cell reports
|May 12, 2024
PubMed
概括

杜比基因酶USP7通过通过RUNX3.3.增强Sα转录促进免疫球蛋白A (IgA) 类切换. 由于USP7的耗尽,导致异常的IgG切换,通过损害Sα转录和促进循环挤出.

关键词:
B 细胞 B 细胞CP: 免疫学 免疫学在CSR中,CSR是指CSR.造成的DNA损伤是DNA损伤.USP7 USP7 美国胚胎线转录的发生.循环挤出循环的挤出.

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