基因组 lysine 甲基转移酶 MLL1 调节调节性T细胞的激活和功能专业化

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Updated: Jun 26, 2025

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
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Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

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Ting Wang1, Jie Guo2, Liping Li1

  • 1CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Science (CAS), Beijing 100101, China; Department of Savaid Medical School, University of the Chinese Academy of Sciences, Beijing 100049, China.

Cell reports
|May 12, 2024
PubMed
概括

氨基甲基转移酶MLL1对于调节性T细胞 (Treg) 功能至关重要. 缺乏MLL1会损害Treg的激活和专业化,导致小鼠自身免疫性疾病.

关键词:
CP: 免疫学 免疫学H3K4三甲基化三甲基化在MLL1中,MLL1是MLL1在T-bet上下注.这就是Treg Treg.这是自身免疫力.

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