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和多醇基物质 (PFAS) 和胎儿生长:基于饮用水中PFAS的全国性注册研究

Melle Säve-Söderbergh¹, Irina Gyllenhammar², Tessa Schillemans³

¹Risk- and Benefit Assessment Department, Swedish Food Agency, Uppsala, Sweden; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Environment international

|May 12, 2024

概括

孕产妇暴露于per-和多基物质 (PFAS) 与妊娠年龄大 (LGA) 出生的风险更高有关. 没有发现与出生体重或妊娠年龄小 (SGA) 结果的关联.

科学领域:

环境健康环境健康
生殖流行病学生殖流行病学
毒理学毒理学毒理学

背景情况:

关于和多基基物质 (PFAS) 与胎儿生长之间的关联,有不确定的证据.
这项研究解决了需要更清楚地了解PFAS对妊娠结果的影响的需求.

研究的目的:

评估母亲暴露于四种PFAS (PFAS4:PFOS,PFOA,PFNA,PFHxS) 的总和和出生体重,妊娠年龄小 (SGA) 和妊娠年龄大 (LGA) 之间的关联.

主要方法:

瑞典 (2012-2018) 全国范围的基于登记的队列研究,包括248,804个单独出生.
在怀孕期间使用毒动力学模型估计母亲的累积PFAS4血度,将住宅病史和市政水中的PFAS度联系起来.
分析了使用线性回归和逻辑回归以及混合效应的量子g计算的关联.

主要成果:

PFAS4与出生体重或SGA之间没有总体关联.
在更高的PFAS4暴露和LGA风险增加之间观察到一个显著的关联 (OR 1.08,95%CI: 1.01-1.16)).
混合物效应分析表明,PFOS,PFNA和PFHxS有助于增加LGA风险.

结论:

母亲暴露于PFAS4的总和,特别是PFOS,与分娩出大胎儿的风险增加有关.
没有发现与总出生体重或SGA的相关性.
暴露评估的局限性要求谨慎解释发现.

关键词:

出生的体重出生时的体重.胎儿的成长胎儿的成长对于怀孕年龄来说是很大的.-和多基基物质.对于怀孕年龄来说小.

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