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与长期鼻癌幸存者的耳毒性相关的危险因素
Shuangshuang He1, Hang Yu2, Ling He3
1Department of Radiation Oncology and Department of Head and Neck Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Oral oncology
|May 12, 2024
概括
耳毒性是长期接受强度调节放射治疗的鼻癌幸存者中患者报告的最常见的结果. 50岁以上的年龄,糖尿病和特定的辐射剂量是严重耳毒性的关键危险因素.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 患者报告的结果
背景情况:
- 鼻癌 (NPC) 幸存者经常经历长期的副作用.
- 了解患者报告结果 (PROs) 对于改善生活质量至关重要.
- 强度调节放射治疗 (IMRT) 是NPC的标准治疗方法.
研究的目的:
- 调查长期鼻癌幸存者的患者报告结果.
- 识别与常见症状相关的危险因素,特别是耳毒性.
- 为更好的治疗和症状管理策略提供信息.
主要方法:
- 对223名接受激进IMRT治疗的NPC患者进行了回顾性研究 (2009年6月至2016年6月).
- 通过随访分析疾病状况和患者报告的结果.
- 使用常用术语标准对不良事件 (CTCAE) 版本5.0.0进行耳毒性分级.
主要成果:
- 耳毒性是最常见的PRO,影响了52.9%的患者.
- 3-4级耳毒性的独立风险因素包括年龄≥50岁,糖尿病,D2剂量≥69 Gy,V35剂量≥91.5%.
- 3-4级耳毒性与其他症状的风险增加相关,如失声症,舌头功能障碍,声,消症和眼部毒性.
结论:
- 在长期接受IMRT治疗的NPC幸存者中,耳毒性是主要的PRO.
- 年龄,糖尿病和特定的辐射剂量参数 (D2和V35) 是严重耳毒性的重要危险因素.
- 这些发现有助于针对性管理和NPC患者的风险分层.
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