在精神分裂症中,过度的左前海马和尾骨激活是虚拟导航任务中认知表现不佳的基础
John A Zawadzki1, Todd A Girard2, James Samsom3
1Institute of Medical Science, University of Toronto, ON, Canada; Centre for Addiction & Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON, Canada.
Psychiatry research. Neuroimaging
|May 12, 2024
概括
精神分裂症谱系障碍 (SSD) 患者在虚拟导航期间显示出不同的大脑活动模式,影响空间记忆和导航策略. 这些发现可能会为SSD患者的认知补救方法提供信息.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症谱系障碍 (SSD) 与认知缺陷有关,特别是在空间导航方面.
- 了解这些缺陷的神经解剖学基础对于开发有效干预措施至关重要.
研究的目的:
- 调查SSD患者在空间导航中的认知缺陷的神经解剖相关性.
- 在虚拟导航任务中使用功能磁共振成像 (fMRI) 检查大脑活动.
主要方法:
- 使用了一个虚拟城市导航范式,有36名参与者 (18名SSD,18名控制).
- 在快速,单次的导航任务中收集的fMRI数据,评估目标的发现和路径的追踪.
- 进行了先验感兴趣区域分析,专注于海马,尾状和背侧前额皮层.
主要成果:
- SSD患者表现出受损的目标寻找和减少快捷方式形成,并增加了路径回溯.
- SSD参与者显示左海马 (被动观看) 和左尾状 (目标发现) 的过度激活.
- 在SSD患者的初始目标呈现期间,在背侧前额叶皮层观察到低活化.
结论:
- 观察到的大脑行为关系表明,在SSD中偏向于刺激-反应导航.
- 这些导航障碍可能源于异心空间记忆的困难,影响有效的导航.
- 这些发现可以指导开发针对SSD的有针对性的认知补救策略.
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