在经过修改的自然循环中,胚胎转移当天的孕激素度在冷胚胎转移周期中
Marte Saupstad1, Sara J Bergenheim2, Jeanette W Bogstad2
1The Fertility Clinic, Department of Gynaecology, Fertility and Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark..
Reproductive biomedicine online
|May 12, 2024
概括
在经过修改的自然循环中,在没有黄体阶段支持的情况下,在冷胚胎细胞转移当天的血清孕水平不会影响临床怀孕率. 这一发现表明,在这种特定的生育治疗场景中,孕激素水平不是怀孕成功的可靠预测指标.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精过程中受精.
- 临床怀孕结果临床怀孕结果
背景情况:
- 修改自然循环冷胚胎细胞转移 (mNC-FET) 是激素支持循环的替代方案.
- 在没有质阶段支持 (LPS) 的mNC-FET中转移日内源性孕激素水平的作用仍然不清楚.
- 了解mNC-FET成功的预测因素对于优化患者护理至关重要.
研究的目的:
- 为了研究胚胎移植当天血清孕激素度和临床怀孕率 (CPR) 在没有LPS的mNC-FET接受妇女之间的关联.
- 确定孕激素水平是否可以预测怀孕结果,包括临床怀孕,怀孕率和怀孕丧失率 (PLR).
主要方法:
- 一项随机对照试验的子研究包括209名没有LPS的mNC-FET接受的妇女.
- 血清孕激素水平测量是在单个母细胞囊移植的那一天.
- 妇女被分为低孕激素和高孕激素组,使用第10个和第25个百分位数作为切断点.
- 使用多变量逻辑回归分析来调整混因素.
主要成果:
- 血清孕激素度在4.9至91.8nmol/l之间,第25个和第10个百分点分别为29.0和22.5nmol/l.
- 在获得临床怀孕的妇女和没有获得临床怀孕的妇女之间没有观察到孕水平的显著差异 (38.5与36.8nmol/l,P=0.350).
- 临床怀孕率,整体怀孕率和怀孕流产率在不同的孕激素度组中相似.
结论:
- 胚胎囊移植当天的血清孕激素度与在没有叶期支持的情况下接受多重FET的妇女的怀孕结果无关.
- 转移当天内源性孕激素水平似乎不是在这个特定的试管婴儿方案中成功的预测标记.
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