肝氧化变化和症状性静脉透析性低血压
Susumu Ookawara1, Kiyonori Ito1, Yusuke Sasabuchi2
1Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
在血液透析 (HD) 期间的肝氧化监测可以预测内透析性低血压 (IDH). 肝脏氧和降低在患有和没有症状的IDH患者之间显著不同.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生理学 生理学 生理学
- 医疗监测 医疗监测
背景情况:
- 有限的研究比较了血液透析 (HD) 期间脑和肝氧化变化,这些研究对有和没有内透析性低血压 (IDH) 的患者进行.
- 调查组织氧化差异对于了解HD相关并发症至关重要.
研究的目的:
- 为了比较有症状的IDH和没有症状的患者之间脑和肝氧化的内射分析变化.
- 为了确定肝脏氧化的变化是否可以预测在HD期间的症状IDH.
主要方法:
- 分析了109名患有HD的患者的数据,比较了具有 (n=23) 和没有 (n=86) 症状的IDH患者.
- 使用INVOS 5100c监视器监测大脑和肝脏区域氧和 (rSO2).
- 与静脉血压 (SBP) 的最低点相对比较rSO2变化.
主要成果:
- 大脑rSO2变化在各组之间没有显著差异.
- 与没有症状的患者相比,有症状的IDH患者的肝脏rSO2显著下降 (p < 0.001).
- 肝脏rSO2的变化显示出对症状IDH发病的良好预测能力 (AUC高达0.847).
结论:
- 在HD期间肝氧化率下降是症状IDH的显著预测因素.
- 大脑氧化变化不能可靠地区分IDH和没有IDH的患者.
- 监测肝氧化可能有助于预测和管理血液透析期间的IDH.
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