PD-L1基因多态性和与使用固体燃料的相互作用对结核病的影响
Kun Tang1,2, Jing Wang3, Hua Zhong4
1Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha, China.
Public health genomics
|May 12, 2024
概括
中国汉族人群的结核病 (TB) 易感性与特定的PD-L1基因变异 (rs4143815) 有关. 这种遗传因素与固体燃料造成的室内空气污染相互作用,增加结核病风险.
科学领域:
- 免疫遗传学 免疫遗传学
- 环境健康 环境健康
- 传染性疾病 传染性疾病
背景情况:
- 编程死亡配体1 (PD-L1) 是T细胞介导免疫反应的关键调节者.
- 结核病 (TB) 仍然是一个重大的全球健康挑战,特别是在某些人群中.
研究的目的:
- 调查PD-L1基因多态化与中国汉族人群结核病易感性之间的关联.
- 评估PD-L1基因变异和暴露于固体燃料造成的室内空气污染与结核病风险之间的相互作用.
主要方法:
- 一项涉及503名结核病患者和494名健康对照者的病例控制研究.
- 使用质谱法对PD-L1基因单核酸多态 (SNP) rs2297136和rs4143815的基因定型.
- 使用无条件逻辑回归和边际结构线性几率模型进行统计分析,以评估SNP关联和基因环境相互作用.
主要成果:
- 在PD-L1基因中的rs4143815多态性与增加的结核病易感性显著相关 (GG基因型:OR 3.074;CG+GG基因型:OR 1.506).
- 在rs2297136 SNP和结核病风险之间没有发现显著的关联.
- 在rs4143815多态和用固体燃料之间观察到显著的积极相互作用 (相对过度相互作用风险:2.365),表明结核病的风险增加.
结论:
- PD-L1基因的rs4143815多态性是中国汉族人群结核病易感的一个危险因素.
- 暴露于固体燃料造成的室内空气污染与rs4143815 PD-L1基因型显著相互作用,放大了结核病易感性.
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