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冈比亚家庭中Streptococcus pyogenes携带和感染:纵向队列研究
Edwin P Armitage1, Gabrielle de Crombrugghe2, Alexander J Keeley3
1Vaccines and Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, The Gambia; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
The Lancet. Microbe
|May 12, 2024
概括
在冈比亚,Streptococcus pyogenes携带和感染很常见,特别是在儿童中. 皮肤携带和皮肤炎在家庭传播中发挥着关键作用,观察到皮肤和喉之间的双向传播.
科学领域:
- 微生物学 微生物学
- 流行病学 流行病学
- 传染性疾病 传染性疾病
背景情况:
- 杆菌 (Streptococcus pyogenes) 是一个主要的全球病原体,每年造成超过50万人的死亡,不成比例地影响低收入和中等收入国家.
- 在疾病传播中S. pyogenes皮肤和喉携带的确切作用仍然不完全理解.
- 研究这些动态对于在高负荷环境中制定有效的控制策略至关重要.
研究的目的:
- 为了调查Streptococcus pyogenes的临床流行病学.
- 为了阐明S. pyogenes无症状携带和感染的家庭传播动态.
- 在高负荷环境中识别风险因素和传播模式.
主要方法:
- 在冈比亚的苏库塔进行了一年的前性纵向家庭队列研究.
- 为S. pyogenes培养采集了每月的喉和皮肤拭子,并收集了社会人口统计数据.
- 事件感染 (喉炎,皮肤炎) 被捕获,分离物经历了 emm 的基因定型.
主要成果:
- 观察到S. pyogenes携带 (喉和皮肤) 和疾病 (皮肤病最常见) 的高发病率,特别是在儿童中.
- 喉携带和喉炎风险与雨季和更大的家庭规模有关.
- 在幼儿和男性中,皮肤携带和皮肤炎风险更高,皮肤炎是家庭传播的重要来源.
结论:
- 在冈比亚,Streptococcus pyogenes的携带和感染非常普遍,儿童尤其受到影响.
- 虽然大多数感染是在家庭之外获得的,但皮肤携带和皮肤炎是家庭内传播的重要驱动因素.
- 在皮肤和喉部之间记录了双向传播,突出了复杂的传播途径.
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