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Updated: Jun 26, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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向STAT3增强了CDK4/6抑制剂治疗在头部和部状细胞癌的作用

Lin Dong1, Chao Liu1, Haoyang Sun2

  • 1Department of Maxillofacial and Otorhinolaryngological Oncology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China; Key Laboratory of Basic and Translational Medicine on Head & Neck Cancer, Tianjin, 300060, China; National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin, 300060, China.

Cancer letters
|May 12, 2024
PubMed
概括

CDK4/6抑制剂在头部和部状细胞癌 (HNSCC) 中表现出有限的疗效. 通过对MYC进行上调,STAT3信号驱动电阻,导致RB缺乏. 将Stattic与CDK4/6抑制剂相结合,为HNSCC提供了一个有前途的治疗策略.

关键词:
这是一种CDK4/6抑制剂.药物敏感性 药物敏感性头部和部状细胞癌瘤在 RB RB RB 的位置上.STAT3活动活动.

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