科尔迪塞普斯:缓解缺血性心血管和脑血管损伤 - 一个全面的审查
Yong Li1, Liying He1, Haoran Song1
1College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Journal of ethnopharmacology
|May 12, 2024
概括
科迪塞普斯在治疗缺血性心脑血管疾病 (CCVDs) 中表现有前途. 本次审查强调了其保护大脑和心肌缺血/反损伤 (CI/RI和MI/RI) 的潜力.
科学领域:
- 药理学和传统医学的医学.
- 心血管和神经学研究.
背景情况:
- 科迪塞普斯是一种在传统中医药 (TCM) 中具有悠久历史的草药,因其治疗性质而闻名.
- 缺血性心脑血管疾病 (CCVD),如大脑和心肌缺血性/反损伤 (CI/RI和MI/RI),是导致人类死亡和残疾的主要原因.
- 现有的研究表明,Cordyceps对这些疾病具有生物活性,但缺乏全面的审查.
研究的目的:
- 在缺血性CCVDs的背景下调查Cordyceps的化学成分,药理作用,临床应用和安全性.
- 巩固当前关于Cordyceps在管理大脑和心肌缺血/再输液损伤中的作用的知识.
主要方法:
- 在包括Web of Science,PubMed,CNKI和Wanfang在内的主要科学数据库中进行了系统的文献搜索.
- 在搜索中使用的关键词包括"皮质","脑缺血/反损伤"和"心肌缺血/反损伤",以及它们的同义词.
- 检索的研究被系统地分类和总结,以提供全面的概述.
主要成果:
- 科迪塞普斯及其生物活性成分 (adenosine,cordycepin,mannitol,多糖,蛋白质) 显示出对CI/RI和MI/RI的保护作用.
- 作用机制包括改善血液输液,减轻氧化应激,减少炎症,预防亡,促进组织再生.
- 科尔迪塞普斯还可以解决缺血的潜在因素,如高血压,血栓,动脉样硬化和心律失常,同时改善心脏能量代谢和减少神经元刺激毒性.
结论:
- 科迪塞普斯在CI/RI和MI/RI的预防和治疗方面表现出显著的潜在疗效和安全性.
- 这些发现为治疗缺血性CCVD提供了新的见解,强调了Cordyceps的治疗价值.
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