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基于核酸的电化学生物传感器

Balu Mahendran Gunasekaran¹, Soorya Srinivasan², Madeshwari Ezhilan³

¹School of Chemical & Biotechnology (SCBT), SASTRA Deemed University, Thanjavur 613 401, Tamil Nadu, India; Center for Nanotechnology & Advanced Biomaterials (CENTAB), SASTRA Deemed University, Thanjavur 613401, Tamil Nadu, India.

Clinica chimica acta; international journal of clinical chemistry

|May 12, 2024

概括

本综述探讨了用于早期疾病诊断的基于核酸的电化学生物传感器. 这些先进的基因传感器为检测癌症,DNA损伤和病毒感染提供了有前途的护理解决方案.

科学领域:

生物医学工程生物医学工程
生物传感技术的技术
分子诊断学分子诊断

背景情况:

结肠直肠癌,乳腺癌,氧化性DNA损伤和病毒感染带来了重大的诊断挑战.
基于核酸的电化学平台对于临床诊断和生物感知至关重要.
早期疾病检测仍然是医疗保健中至关重要的未满足需求.

研究的目的:

对先进的电化学基因传感器设备的生物传感器设计策略进行审查.
探索DNA固定化技术及其在疾病诊断中的应用.
突出生物识别元素和纳米接口在基因传感器开发中的作用.

主要方法:

专注于对基于核酸的电化学生物传感器的现有文献进行审查.
对基因传感器件的设计原则的分析.
在电极表面对DNA的固定策略的检查.
对用于生物标志物检测的生物识别元素和纳米接口的审查.

主要成果:

电化学基因传感器在癌症,白血病,氧化DNA损伤和病毒病原体的早期诊断中显示出有用性.
先进的设计包括特定的生物识别元素和纳米接口,以加强检测.
为了优化传感器性能,采用了各种DNA固定方法.

结论:

基于核酸的电化学生物传感器是早期疾病检测的重要工具.
需要进一步的研究来应对敏感性,选择性和检测极限方面的挑战.
本综述为生物医学应用制造和理解这些生物传感器提供了洞察力.

关键词:

癌症癌症癌症癌症造成的DNA损伤是DNA损伤.电化学基因传感器电化学基因传感器核酸 - 核酸是一种核酸.病毒病毒病毒

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