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微塑料在鱼类中的免疫毒性

Huiqi Li¹, Huanpeng Liu¹, Liuliu Bi¹

¹Affiliation: Institute of Life Sciences & Biomedicine Collaborative Innovation Center of Zhejiang Province, College of Life and Environmental Science, Wenzhou University, Wenzhou, 325035, China.

Fish & shellfish immunology

|May 12, 2024

概括

微塑料 (MP) 通过破坏器官和破坏免疫细胞来损害鱼类的免疫力. 需要进一步的研究来了解MP的免疫毒性及其与污染物的联合作用.

科学领域:

环境毒理学环境毒理学
水生生态学水生生态学
免疫学免疫学免疫学

背景情况:

水生环境中的塑料废物降解为微塑料 (MP) 和纳米塑料 (NP).
MP和NP被水生生物摄入,造成物理和化学伤害.
鱼类的免疫系统对防御水borne病原体和污染物至关重要.

研究的目的:

审查MP对鱼类免疫系统的有害影响.
检查国会议员的免疫毒性,单独和与环境污染物相结合.
确定鱼类免疫毒性研究的研究缺口和未来方向.

主要方法:

对鱼类微塑料免疫毒性研究的文献综述.
分析免疫反应,包括细胞招募和器官损伤.
评估免疫标记物的变化,如细胞因子,基因表达和 lysosomal 活动.

主要成果:

国会议员在身体上损害鱼,肝脏和肠道,并进入细胞.
暴露会改变免疫细胞的信号传递,细胞因子水平和基因表达,导致免疫平衡的破坏.
最初的免疫细胞招募 (巨细胞,T细胞) 随后是亡,降低了 lysosomal 容量和补充水平.

结论:

微塑料对鱼类的免疫功能构成重大风险,损害了特定免疫力.
国会议员可以与污染物和病毒结合,可能调节免疫反应.
对MP特性,添加剂和与其他污染物结合作用的全面研究对于了解鱼类免疫毒性及其对人类健康的影响至关重要.

关键词:

鱼类鱼类鱼类鱼类鱼类免疫接种免疫接种免疫毒性免疫毒性海洋污染海洋污染微塑料是一种微塑料.纳米塑料是一种纳米塑料.

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