在 paragangliomas 和 pheochromocytomas 中的无线电治疗术
Stefan Prado Wohlwend1, Pilar Bello Arques1,
1Servicio de Medicina Nuclear, Hospital Universitario y Politécnico La Fe, Valencia, Spain; Clinical Center of Excellence Pheo Para Alliance.
概括
放射性连接体疗法 (RLT) 提供了一种安全有效的治疗方法,用于对准结瘤和发红细胞瘤 (PPGLs). 使用[131I]MIBG或[177Lu]Lu-DOTA-TATE,RLT在患有进展性或症状性PPGL的患者中实现了高的疾病控制率.
科学领域:
- 内分泌学 在内分泌学.
- 核医学就是核医学.
- 在瘤学瘤学.
背景情况:
- 帕拉格林瘤和叶染色细胞瘤 (PPGLs) 是一种罕见的神经内分泌瘤.
- 诊断和治疗计划依赖于功能成像.
- 放射性干疗法 (RLT) 是一种新兴的治疗选择,用于高级PPGLs.
研究的目的:
- 提供PPGL生物学的全面概述.
- 讨论用于诊断和治疗规划的功能成像技术.
- 在PPGL管理中详细说明RLT的应用和结果.
主要方法:
- 对PPGL和RLT的当前文献的审查.
- 诊断功能成像模式的解释.
- 放射性干治疗选择的描述: [131I]MIBG和[177Lu]Lu-DOTA-TATE.
- 讨论RLT的使用,标准和不良影响.
主要成果:
- 使用[131I]MIBG或[177Lu]Lu-DOTA-TATE的RLT,根据功能成像中显示的目标表达表示.
- 追溯数据表明,RLT是安全的,并且在PPGL中耐受良好.
- 在缓慢到中度进展或有症状的病例中,RLT可以达到高的疾病控制率.
结论:
- RLT代表了针对PPGL患者的个性化医疗方法.
- 对于一些PPGL患者来说,它是一种可行的治疗选择.
- 在管理高级或有症状的PPGL方面,RLT显示出显著的潜力.
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