饮食炎症指数和饮食模式与2型糖尿病患者轻度认知障碍的相关性
Shengdan Pu1, Yuxin Xu1, Xuewei Tong1
1Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Endocrinologia, diabetes y nutricion
|May 12, 2024
概括
坚持地中海式饮食可能会降低2型糖尿病 (T2DM) 患者轻度认知障碍 (MCI) 的风险. 相反,高肉类和低蔬菜摄入量,或西方饮食,增加MCI风险,与饮食.
科学领域:
- 营养神经科学 营养神经科学
- 代谢障碍 代谢障碍 代谢障碍
- 认知健康 认知健康
背景情况:
- 2型糖尿病 (T2DM) 与认知能力下降的风险增加有关.
- 轻度认知障碍 (MCI) 是痴呆症的前体,需要识别T2DM人群中可修改的风险因素.
研究的目的:
- 在T2DM患者中调查与MCI相关的饮食模式.
- 检查T2DM患者的饮食炎症指数 (DII) 和MCI之间的相关性.
- 探索DII在饮食模式和MCI之间的关系中的调解作用.
主要方法:
- 使用蒙特利尔认知评估 (MoCA) 评估的认知功能.
- 通过食物频率问卷收集的饮食摄入数据来计算DII.II.
- 使用降级回归识别的饮食模式;用于相关性和剂量反应分析的物流回归和受限制的立方线.
主要成果:
- 坚持地中海式饮食与较低的MCI几率 (OR=0.37) 有关.
- 高肉/低蔬菜和西方风格的饮食与增加MCI几率有关 (分别为OR=6.84和OR=2.48).
- 较高的DII分数与较高的MCI几率相关 (OR=3.99);DII部分介导了饮食模式对MCI的影响.
结论:
- 地中海风格的饮食模式对T2DM中MCI有保护作用.
- 肉类和加工食品的高消费,以及低蔬菜摄入量,增加了MCI风险.
- 高DII表示的促炎饮食与T2DM中MCI患病率较高有关,DII调解饮食模式的影响.
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