晚期和晚期早产婴儿的早期与晚期亲肠道营养:一个随机对照试验
Kwi Moon1,2, Elizabeth McKinnon3, Kevin Croft4
1Pharmacy Department, Perth Children's Hospital, Nedlands, Western Australia, Australia kwi.moon@health.wa.gov.au.
BMJ paediatrics open
|May 12, 2024
概括
开始产肠道营养 (PN) 早期和晚期的早产婴儿没有影响氧化压力,但增加了氨酸水平和高血糖症. 需要对早期PN的临床结果进行进一步的研究.
科学领域:
- 新生儿医学 新生儿医学
- 临床营养学 临床营养学
- 儿科研究 儿科研究
背景情况:
- 有限的证据表明,对于期满和晚期早产婴儿的最佳腹腔营养 (PN) 时间是有限的.
- 对于需要营养支持的婴儿来说,腹腔营养非常重要.
- 了解PN时间影响临床结果和代谢标志物.
研究的目的:
- 调查早期与晚期亲肠道营养 (PN) 开始对期末和晚期早产婴儿的氧化应激和代谢概况的影响.
- 评估PN时间对产后生长和诸如高血糖症等不良事件的影响.
主要方法:
- 一个单中心,非盲目的,探索性随机受控试验,涉及怀孕≥34周出生的婴儿.
- 婴儿接受了早期PN (1日或2日) 或晚期PN (6日).
- 测量了血类氨酸,F2-异质水平,氨基/脂肪酸概况和临床结果.
主要成果:
- 早期PN开始导致4日血 fenylalanine水平较高,但不是8日.
- 两组之间没有观察到氧化应激标志物 (F2-异素) 的显著差异.
- 早期的PN与较不严重的体重增长限制有关,但高血糖的发病率较高.
结论:
- 在重症婴儿中,PN启动的时间并没有显著改变氧化应激.
- 过渡性升高的氨与早期PN值得进一步调查临床影响.
- 早期PN可能会减少生长限制,但会增加高血糖症的风险.
关键词:
新生儿科学 新生儿科学相关概念视频
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