喉微生物群驱动肺膜微生物群的变化,在患有败血性ARDS的患者
Na-Na Li1, Kai Kang1, Yang Zhou1
1Departments of Critical Care Medicine, the First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, Heilongjiang, China.
Virulence
|May 13, 2024
概括
在感染性急性呼吸窘迫综合征 (ARDS) 患者中,肺部微生物群主要来自喉,而不是肠道. 肠道菌群是什么意思 肠道菌群
科学领域:
- 微生物学 微生物学
- 肺部病理学 肺部病理学
- 关键护理医学 关键护理医学
背景情况:
- 肠道菌群的转移与性ARDS下呼吸道殖民有关.
- 这种转位是ARDS患者的关键预后因素.
研究的目的:
- 调查感染性ARDS患者的肺微生物群的起源和动态.
- 确定喉和肠道菌群对肺微生物群组成的贡献.
主要方法:
- 在第1天和第3天从ICU患者收集了支气管洗液 (BALF),喉和门拭子.
- 利用16S rRNA测序和下一代技术进行微生物分析.
主要成果:
- 在第一天,85.16%的肺微生物来自喉,只有5.79%来自肠道.
- 在两个采样日,喉微生物群在BALF中占主导地位,随着ARDS的进展,肠道菌群的比例略有增加.
- 微生物群组成显示了BALF和喉样本之间的一致性.
结论:
- 在败血性ARDS中,肺微生物的主要来源是喉.
- 虽然肠道菌群转移是可能的,但喉起源更为重要.
- 肺部微生物群的动态在ARDS早期和晚期之间是一致的.
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