一个具有刚性导管的弹性血管中血流的一维计算模型
Aseem Milind Pradhan1, Fernando Mut1, Juan Raul Cebral1
1Bioengineering Department, George Mason University, Fairfax, Virginia, USA.
概括
一个新的1D数学模型模拟了用于中风治疗计划的血液流动. 这种计算流体动力学方法提供了复杂的血管网络的准确,高效的模拟,有助于患者特定的干预.
科学领域:
- 生物医学工程 生物医学工程
- 计算流体动力学的流体动力学.
- 数学建模的数学建模
背景情况:
- 卒中是导致死亡的主要原因,需要复杂的内血管治疗.
- 目前的3D计算流体动力学 (CFD) 解决方案太慢,无法规划涉及大动脉网络的患者特异性中风干预.
研究的目的:
- 开发一种新的,计算效率高的1D数学模型,用导管模拟弹性血管中的血液流动.
- 为了实现系统的,针对患者的治疗规划内血管中风干预措施.
主要方法:
- 一个1D数学公式,使用一阶过度的部分微分方程被开发出来.
- 使用不连续的加勒金方法来解决超标系统.
- 该1D模型与使用理想化和现实的动脉网络的3D CFD解决器进行了验证.
主要成果:
- 与3D CFD相比,1D模型在稳定流量情况下显示出临床上微不足道的差异 (变化<10%).
- 在不稳定的流动模拟中观察到波反射现象的准确捕获.
- 一维模型可以更轻松地对具有多个分支的复杂血管进行分离.
结论:
- 一维计算模型为模拟复杂的血管几何形状提供了准确性和效率的良好平衡.
- 这种方法显示出有很大的潜力,可以推进患者特定的模拟和内血管中风干预的规划.
更多相关视频
07:30In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
Published on: November 3, 2015
9.6K
08:44An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices
Published on: August 21, 2020
7.1K
相关概念视频
Steady, Laminar Flow in Circular Tubes
192
Hagen-Poiseuille flow describes a viscous fluid's steady, incompressible flow through a cylindrical tube with a constant radius R. This flow profile is often applied to understand fluid transport in narrow channels, such as capillaries. It serves as a foundational example of laminar flow. In this model, cylindrical coordinates (r,θ,z) are used to describe the radial (r), angular (θ), and axial (z) dimensions within the tube. For Hagen-Poiseuille flow, the velocity profile is...
192
Typical Model Studies
356
Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
356
The Buckingham Pi Theorem
621
The Buckingham Pi theorem provides a structured method to simplify fluid dynamics problems by reducing complex systems of variables to dimensionless terms.
621
Couette Flow
249
Couette flow represents the flow of fluid between two parallel plates, with one plate fixed and the other moving with a constant velocity. This configuration allows for a simplified analysis using the Navier-Stokes equations, which govern fluid motion under conditions of viscosity and incompressibility. For Couette flow, the assumptions include a steady, laminar, incompressible flow with a zero-pressure gradient in the flow direction. This flow type is beneficial for understanding shear-driven...
249
