与疾病相关的变量对风湿性关节炎患者骨矿物质密度的影响
Sachin Naik1, Archana Sonawale2, Kshitij Sonawale3
1Senior Resident, Department of Nephrology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.
概括
类风湿性关节炎 (RA) 显著影响患者的骨矿物质密度 (BMD). 晚年,更长的疾病持续时间,身体残疾,类风湿因子阳性和长期使用类固醇是导致 BMD 降低的关键因素.
科学领域:
- 类风湿病学 类风湿病学
- 骨的新陈代谢 骨的新陈代谢
- 骨质疏松症研究 骨质疏松症研究
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性炎症状况,影响骨健康.
- 影响RA患者骨矿物质密度 (BMD) 变化的确切因素仍在调查中,疾病进展,不运动和药物是潜在的贡献者.
研究的目的:
- 调查类风湿性关节炎和骨矿物质密度 (BMD) 之间的关系.
- 分析人口统计因素,疾病活动,功能障碍,疾病持续时间,类固醇使用和类风湿因子 (RF) 标位与RA患者的BMD的相关性.
主要方法:
- 一项涉及96名根据ACR/EULAR标准诊断的类风湿性关节炎患者的横截面研究.
- 使用双能X射线吸收计 (DEXA) 评估的骨矿物质密度 (BMD).
- 疾病活动用DAS28-ESR测量,功能残疾用HAQ得分测量;统计分析包括t测试和Chi平方测试.
主要成果:
- 随着年龄的增加,较长的RA持续时间和更高的功能障碍 (HAQ分数) 观察到 BMD 降低.
- 类风湿因子 (RF) 阳性与部区域的骨质量减少有关.
- 长期使用皮质类固醇 (≥30天) 在所有测量部位 (腰椎,大腿部部,全部) 显著降低了BMD.
- 疾病严重程度 (DAS28-ESR) 与骨硬化没有显著的相关性.
结论:
- 类风湿性关节炎会对骨矿物质密度产生不利影响.
- 诸如晚年,疾病持续时间,身体残疾,射频阳性和长期的皮质类固醇治疗等因素是RA患者骨髓质量损失的重要决定因素.
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