怀孕高血压中的交感神经功能测试和与孕前和孕后发展的关系:来自临床药理学诊所的现实世界证据
Shambo Samrat Samajdar1, Sougata Sarkar2, Avishek Bhadra3
1Clinical Pharmacologist and Consultant at Diabetes and Allergy-Asthma Therapeutics Specialty Clinic, Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, West Bengal, India, Corresponding Author.
概括
孕期高血压与同情活动的增加有关,在握手炼后,腹压血压的显著上升表明了这一点. 这种同情性过度活跃与怀孕个体的孕前和孕后的发展相关.
科学领域:
- 产科和妇科 产科和妇科
- 心血管生理学心血管生理学
- 自主神经系统研究 自主神经系统研究
背景情况:
- 孕期高血压对母亲和胎儿的健康构成风险,可能会发展为孕前.
- 正常的怀孕涉及自主活动的转变,与降低的副交感和增加的交感音调.
- 同情神经功能的异常可能存在于妊娠高血压中,并与子宫前/子宫的发展有关.
研究的目的:
- 为了研究妊娠高血压中的交感神经功能异常.
- 确定这些异常与产前/产后的发展之间的关联.
主要方法:
- 一项前性观察性研究,涉及52名妊娠高血压患者和52名匹配对照.
- 自主神经功能测试,包括同度手握 (IHG) 和IHG后的透析血压 (DBP) 变化 (Δ DBP).
- 与此同时进行了24小时尿蛋白检测.
主要成果:
- 与对照组相比,孕期高血压患者 (PIH臂) 的IHG前DBP,IHG后DBP和ΔDBP显著更高.
- 在PIH手臂中,在Δ DBP和24小时蛋白尿之间发现了显著的正相关性.
- 该PIH组包括15名多重孕和37名初重孕的参与者.
结论:
- 在IHG运动后增加的DBP反应是妊娠高血压的特征.
- 这种过度的DBP上升与妊娠前和妊娠后的进展密切相关.
- 准交感性过度活动可能为管理妊娠高血压提供治疗方法.
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